Efficient IgG cleavage with a low immunogenicity risk enzyme, supporting clearance of neutralizing antibodies to improve gene therapy administration.
Applications
Explore how our solutions are used across a range of applications. From sample preparation to advanced analysis, you can find insights into how they support different workflows and help address common challenges.
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Inhibition by synthetic RNase inhibitor (SEQURNA) matches or surpasses recombinant inhibitors in Smart‑seq2 and Smart-seq3 library preparation, including RNase‑rich tissues.
Synthetic RNase inhibition maintains Smart‑seq2 cDNA yield and quality comparable to protein-based RRIs while decreasing primer‑dimer formation.
Simplified charge variant analysis by removing sialic acid-driven heterogeneity to reveal underlying protein profile.
Complete desialylation of complex glycoproteins to simplify glycan profiles and enable more confident protein characterization.
Efficient removal of core 1 O-glycans from complex glycoproteins to reduce heterogeneity and improve mass spectrometry characterization.
Preparation of pure, homogeneous mouse IgG Fab fragments with no residual enzyme by combining FabULOUS digestion and affinity purification.
Simple preparation of highly pure Fab fragments from IgG1 antibodies using FabALACTICA digestion combined with Fc affinity purification.
A simple and rapid estimation of IgG core fucosylation using LC-MS analysis.
Efficient Fab generation for SPR-based separation of affinity and avidity effects, supporting detailed functional characterization of monoclonal antibodies.
Improved characterization of bispecific antibody chain mispairing by FabDELLO subunit digestion and LC-MS resolution of Fab variants.
A simple and rapid estimation of IgG core fucosylation and glycan occupancy using LC-MS analysis.
